Xiang, Y, Fu, T, Xu, Q, Chen, W, Chen, Z, Guo, J, Deng, C, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Wang, P, Zhang, H, Tian, X and Wang, J (2021) Quantitative analysis of internal components of the human crystalline lens during accommodation in adults. Scientific Reports, 11 (1).

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Abstract

Objectives. To quantitatively analyze changes in the inner components of the human crystalline lens during accommodation in adults.
Methods. Eyes of 23 subjects were sequentially examined using CASIA2 Optical Coherence Tomography under 0D, -3D and -6D accommodation states. The anterior chamber depth (ACD), anterior and posterior crystalline lens radius of the curvature (ALRC and PLRC) were obtained using built-in software. The lens thickness (LT), lenticular nucleus thickness (NT), anterior cortex thickness (ACT), posterior cortex thickness (PCT), anterior and posterior lenticular nucleus radius of the curvature (ANRC and PNRC), anterior and posterior lenticular nucleus vertex (ANV and PNV) were quantified manually with the Image-pro plus software.
Results. During accommodation, the ACD became significantly shallower and LT significantly increased. For changes in the lens, the ALRC decreased by an average magnitude （related to accommodative stimuli） 0.44 mm/D and PLRC decreased 0.09 mm/D. There was no difference for the ACT and PCT in different accommodation states. For lenticular nucleus response, NT increased on average by 30μm/D. Both the ANRC and PNRC decreased on average by 212 μm/D and 115 μm/D respectively. The ANV moved forward on average by 0.07mm under -3D accommodative stimuli and 0.16mm for -6D. However, there was no statistically significant difference between different accommodation states in the PNV movement.
Conclusion. Under accommodation stimulation, lens thickness changed mainly due to the lenticular nucleus, but not the cortex. For the lenticular nucleus, both the ANRC and PNRC decreased and ANRC changed the most. The anterior surface of the nucleus moved forward while the posterior surface of the nucleus moved backward but only slightly.
Keywords: crystalline lens, lenticular nucleus, lenticular cortex, accommodation

Item Type:	Article
Identifier:	10.1038/s41598-021-86007-6
Keywords:	crystalline lens, lenticular nucleus, lenticular cortex, accommodation
Subjects:	Medicine and health > Clinical medicine > Clinical care Medicine and health > Clinical medicine Medicine and health
Related URLs:	Publisher
Depositing User:	Anne Manyande
Date Deposited:	09 Mar 2021 13:09
Last Modified:	04 Nov 2024 11:25
URI:	https://repository.uwl.ac.uk/id/eprint/7738

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