Influence of cerebral glucose metabolism by chronic pain–mediated cognitive impairment in adolescent rats

Fang, Yuanyuan, Chen, Chang, Zhong, Qi, Wang, Lirong, Gui, Zhu, Zhu, Jinpiao, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Xu, Fuqiang, Wang, Jie and Zhang, Zongze (2022) Influence of cerebral glucose metabolism by chronic pain–mediated cognitive impairment in adolescent rats. Molecular Neurobiology. ISSN 0893-7648

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Abstract

Chronic pain during adolescence can lead to mental health disorders in adulthood, but the underlying mechanism is still unclear. Furthermore, the homeostasis of cerebral glucose metabolism and neurotransmitter metabolic kinetics are closely associated with cognitive development and pain progression. The present study investigated changes in cognitive function and glucose metabolism in adult rats, which had experienced chronic pain during their adolescence. Here, spared nerve injury (SNI) surgery was conducted in 4-week-old male rats. Mechanical nociceptive reflex thresholds were analyzed, and SNI chronic pain (SNI-CP) animals were screened. Based on animal behavioral tests (open field, three-chambered social, novel object recognition and the Y maze), the SNI-CP animals showed learning and memory impairment and anxiety-like behaviors, compared to SNI no chronic pain (SNI-NCP) animals. The cerebral glucose metabolism in the prefrontal cortex and hippocampus of adult SNI-CP animals was decreased with positron emission tomography/computed tomography. GABA2 and Glu4 levels in the metabolic kinetics study were significantly decreased in the hippocampus, frontal cortex, and temporal cortex, and the expression of GLUT3 and GLUT4 was also significantly downregulated in the prefrontal cortex and hippocampus of adult rats in the SNI-CP group. These findings suggest that the rats which suffered chronic pain during adolescence have lower cerebral glucose metabolism in the cortex and hippocampus, which could be related to cognitive function during the development of the central nervous system.

Item Type: Article
Additional Information: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s12035-022-02816-4
Uncontrolled Keywords: Neuropathic pain, Hippocampus, Cortex, Cognitive impairment, Glucose metabolism, Metabolic kinetics
Subjects: Medicine and health > Clinical medicine > Clinical care
Medicine and health > Clinical medicine
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Depositing User: Anne Manyande
Date Deposited: 26 Apr 2022 14:30
Last Modified: 27 Apr 2022 12:09
URI: http://repository.uwl.ac.uk/id/eprint/9004

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