High-dimensional brain-wide functional connectivity mapping in magnetoencephalography

Sanchez-Bornot, Jose M., Lopez, Maria E., Bruña, Ricardo, Maestu, Fernando, Youssofzadeh, Vahab, Yang, Su ORCID: https://orcid.org/0000-0002-6618-7483, Finn, David P., Todd, Stephen, McLean, Paula L., Prasad, Girijesh and Wong-Lin, KongFatt (2021) High-dimensional brain-wide functional connectivity mapping in magnetoencephalography. Journal of Neuroscience Methods, 348. p. 108991. ISSN 0165-0270

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Abstract

Background
Brain functional connectivity (FC) analyses based on magneto/electroencephalography (M/EEG) signals have yet to exploit the intrinsic high-dimensional information. Typically, these analyses are constrained to regions of interest to avoid the curse of dimensionality, with the latter leading to conservative hypothesis testing.

New method
We removed such constraint by estimating high-dimensional source-based M/EEG-FC using cluster-permutation statistic (CPS) and demonstrated the feasibility of this approach by identifying resting-state changes in mild cognitive impairment (MCI), a prodromal stage of Alzheimer’s disease. Particularly, we proposed a unified framework for CPS analysis together with a novel neighbourhood measure to estimate more compact and neurophysiological plausible neural communication. As clusters could more confidently reveal interregional communication, we proposed and tested a cluster-strength index to demonstrate other advantages of CPS analysis.

Results
We found clusters of increased communication or hypersynchronization in MCI compared to healthy controls in delta (1−4 Hz) and higher-theta (6−8 Hz) bands oscillations. These mainly consisted of interactions between occipitofrontal and occipitotemporal regions in the left hemisphere, which may be critically affected in the early stages of Alzheimer’s disease.

Conclusions
Our approach could be important to create high-resolution FC maps from neuroimaging studies in general, allowing the multimodal analysis of neural communication across multiple spatial scales. Particularly, FC clusters more robustly represent the interregional communication by identifying dense bundles of connections that are less sensitive to inter-individual anatomical and functional variability. Overall, this approach could help to better understand neural information processing in healthy and disease conditions as needed for developing biomarker research.

Item Type: Article
Additional Information: Sanchez-Bornot, J.M., Lopez, M.E., Bruña, R., Maestu, F., Youssofzadeh, V., Yang, S., Finn, D.P., Todd, S., McLean, P.L., Prasad, G., Wong-Lin, K., 2021. High-dimensional brain-wide functional connectivity mapping in magnetoencephalography. Journal of Neuroscience Methods 348, 108991. https://doi.org/10.1016/j.jneumeth.2020.108991
Uncontrolled Keywords: Functional connectivity, Cluster permutation statistics, Nonparametric statistics, Multiple comparison correction, EEG and MEG biomarkers, Alzheimer’s disease
Subjects: Computing
Medicine and health
Related URLs:
Depositing User: Su Yang
Date Deposited: 02 Jun 2021 13:16
Last Modified: 28 Aug 2021 07:15
URI: http://repository.uwl.ac.uk/id/eprint/7920

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