Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method

Yang, Jingyu, Guo, Huiling, Sun, Dandan, Duan, Jia, Rao, Xiaoping, Xu, Fuqiang, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Tang, Yanqing, Wang, Jie and Wang, Fei (2019) Elevated glutamate, glutamine and GABA levels and reduced taurine level in a schizophrenia model using an in vitro proton nuclear magnetic resonance method. American journal of translational research, 11 (9). pp. 5919-5931. ISSN 1943-8141

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Manyande_etal_AJTR_2019_Elevated_glutamate,_glutamine_and_GABA_levels_and_reduced_taurine_level_in_a_schizophrenia_model_using_an_in_vitro_proton_nuclear_magnetic_resonance_method.pdf - Published Version
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Abstract

Accumulating evidence suggests that brain metabolic changes may be associated with the pathophysiology of schizophrenia. Both and studies have found glutamatergic and GABAergic abnormalities in different brain regions of individuals with schizophrenia. We report a longitudinal behavioral study in a methylazoxymethanol acetate (MAM) rat model of schizophrenia at three different age periods: prepuberty, late-puberty and early-adulthood. MAM-treated rats showed stable hypolocomotive activity, anxiety and cognitive deficits from late-puberty to early-adulthood. Therefore we detected the metabolites changes of adult MAM-treated rats using an proton nuclear magnetic resonance ( H-NMR) method. In the MAM-treated rats, glutamate was increased in the thalamus and hypothalamus, glutamine was increased in the hippocampus and GABA was increased in the hippocampus and prefrontal cortex, while taurine showed a decrease in the striatum, temporal cortex and parietal cortex. These abnormalities may be helped further understanding the pathophysiology of schizophrenia. [Abstract copyright: AJTR Copyright © 2019.]

Item Type: Article
Additional Information: This work was supported by the China Postdoctoral Science Foundation (2018M640265) and the Youth Innovation Promotion Association of Chinese Academy of Sciences (Y6Y0021004).
Uncontrolled Keywords: 1H-NMR, GABA, Schizophrenia, glutamate, taurine
Subjects: Medicine and health > Mental health
Medicine and health
SWORD Depositor: Jisc Router
Depositing User: Jisc Router
Date Deposited: 13 Nov 2019 11:05
Last Modified: 13 Nov 2019 11:21
URI: http://repository.uwl.ac.uk/id/eprint/6502

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