Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison

Zhang, Henry, Barnett, Adrian G., Merollini, Katharina, Sutton, Alex, Cooper, Nicola, Berendt, Tony, Wilson, Jennie and Graves, Nicholas (2014) Control strategies to prevent total hip replacement-related infections: a systematic review and mixed treatment comparison. BMJ Open, 4. e003978. ISSN 2044-6055

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Objective: To synthesise the available evidence and estimate the comparative efficacy of control strategies to prevent total hip replacement (THR)-related surgical site infections (SSIs) using a mixed treatment comparison.
Design: Systematic review and mixed treatment comparison.
Setting: Hospital and other healthcare settings.
Participants: Patients undergoing THR.
Primary and secondary outcome measures: The number of THR-related SSIs occurring following the surgical operation.
Results: 12 studies involving 123 788 THRs and 9 infection control strategies were identified. The strategy of ‘systemic antibiotics+antibiotic-impregnated cement +conventional ventilation’ significantly reduced the risk of THR-related SSI compared with the referent strategy (no systemic antibiotics+plain cement+conventional ventilation), OR 0.13 (95% credible interval (CrI) 0.03–0.35), and had the highest probability (47–64%) and
highest median rank of being the most effective strategy. There was some evidence to suggest that ‘systemic antibiotics+antibiotic-impregnated cement +laminar airflow’ could potentially increase infection risk compared with ‘systemic antibiotics+antibiotic impregnated cement+conventional ventilation’, 1.96 (95% CrI 0.52–5.37). There was no high-quality evidence that antibiotic-impregnated cement without
systemic antibiotic prophylaxis was effective in reducing infection compared with plain cement with systemic antibiotics, 1.28 (95% CrI 0.38–3.38). Conclusions: We found no convincing evidence in favour of the use of laminar airflow over conventional ventilation for prevention of THR-related SSIs, yet laminar airflow is costly and widely used. Antibiotic-impregnated cement without systemic antibiotics may not be effective
in reducing THR-related SSIs. The combination with the highest confidence for reducing SSIs was ‘systemic antibiotics+antibiotic-impregnated cement+conventional ventilation’. Our evidence synthesis underscores the need to review current guidelines based on the available
evidence, and to conduct further high-quality doubleblind randomised controlled trials to better inform the current clinical guidelines and practice for prevention of THR-related SSIs.

Item Type: Article
Additional Information: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Subjects: Medicine and health
Medicine and health > Nursing
Depositing User: Jennie Wilson
Date Deposited: 31 May 2016 11:56
Last Modified: 10 Nov 2017 16:32


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