McGregor, Karen F. and Spratt, Brian G. (2005) Identity and prevalence of multilocus sequence typing-defined clones of group A streptococci within a hospital setting. Journal of Clinical Microbiology, 43 (4). pp. 963-1967. ISSN 009-51137

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Abstract

Between July and October 2003, 121 clinical isolates of group A streptococci (GAS) were collected from a London hospital and characterized by multilocus sequence typing (MLST) to determine the identity and prevalence of clones circulating within this setting. A total of 39 sequence types (ST), of which 20 were represented by a single isolate, were identified. The eight most prevalent clones among the 121 GAS were ST117/emm81 (16%), ST39/emm4 (9%), ST62/emm87 (7%), ST28/emm1 (6%), ST36/emm12 (6%), ST46/emm22 (5%), ST334/emm82 (5%), and ST101/emm89 (4%). Compared to those in the MLST database (http://spyogenes.mlst.net), 12 (31%) of the 39 STs had not been previously identified, although 7 of these differed from recognized STs at only a single locus, suggesting they were closely related to previously recognized strains. Resistance to erythromycin and tetracycline was seen in 7 and 20% of isolates, respectively, with four isolates resistant to both agents. GAS strains with higher (>80) emm types accounted for 45% of GAS isolates collected during this study. Continuing GAS surveillance, using easily comparable methods, is important for detecting changes in the character of disease-causing isolates.

Item Type:	Article
Identifier:	10.1128/JCM.43.4.1963-1967.2005
Additional Information:	© 2005 American Society for Microbiology. All Rights Reserved.
Keywords:	Group A streptococci (GAS) ; Multilocus sequence typing (MLST)
Subjects:	Medicine and health > Microbiology
Depositing User:	Rod Pow
Date Deposited:	20 Jul 2012 11:50
Last Modified:	06 Feb 2024 15:39
URI:	https://repository.uwl.ac.uk/id/eprint/91

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