Whole genome sequence and comparative genomics analysis of multi-drug resistant environmental Staphylococcus epidermidis ST59

Xu, Zhen, Misra, Raju, Jamrozy, Dorota, Paterson, Gavin K., Cutler, Ronald R., Holmes, Mark A., Gharbia, Saheer and Mkrtchyan, Hermine (2018) Whole genome sequence and comparative genomics analysis of multi-drug resistant environmental Staphylococcus epidermidis ST59. G3: Genes|Genomes|Genetics, 8 (7). pp. 2225-2230. ISSN 2160-1836

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Staphylococcus epidermidis is a major opportunistic pathogen primarily recovered from device-associated healthcare associated infections (DA-HAIs). Although S. epidermidis and other coagulase-negative staphylococci (CoNS) are less virulent than Staphylococcus aureus, these bacteria are an important reservoir of antimicrobial resistance genes and resistance-associated mobile genetic elements that can be transferred between staphylococcal species. We report a whole genome sequence of a multidrug resistant S. epidermidis (strain G6_2) representing multilocus sequence type (ST) 59 and isolated from an environmental sampling of a hotel room in London, UK. The genome of S. epidermidis G6_2 comprises of a 2408357 bp chromosome and six plasmids, with an average G+C content of 32%. The strain displayed a multi-drug resistance phenotype which was associated with carriage of 7 antibiotic resistance genes (blaZ, mecA, msrA, mphC, fosB, aacA-aphD, tetK) as well as resistance-conferring mutations in fusA and ileS. Antibiotic resistance genes were located on plasmids and chromosome. Comparative genomic analysis revealed that antibiotic resistance gene composition found in G6_2 was partly preserved across the ST59 lineage.

Item Type: Article
Identifier: 10.1534/g3.118.200314
Additional Information: Copyright © 2018 Xuet al. Supplemental material available at Figshare: https://doi.org/10.25387/g3.6133946
Keywords: Staphylococcus epidermidis, antibiotic resistance, whole genome sequence, comparative analysis
Subjects: Medicine and health > Health promotion and public health > Infection prevention
Medicine and health
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Depositing User: Jisc Router
Date Deposited: 16 Sep 2020 15:11
Last Modified: 06 Feb 2024 16:04
URI: https://repository.uwl.ac.uk/id/eprint/7310


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