O'Malley, Mary ORCID: https://orcid.org/0000-0003-3636-6197, Parkes, Jacqueline, Stamou, Vasileios, LaFontaine, Jenny, Oyebode, Jan and Carter, Janet (2019) Young-onset dementia: scoping review of key pointers to diagnostic accuracy. BJPsych Open, 5 (3). pp. 1-9.

Preview

PDF O'Malley_etal_BJPsych_Open_2019_Young-onset_dementia_scoping_review_of_key_pointers_to_diagnostic_accuracy.pdf - Published Version Available under License Creative Commons Attribution. Download (319kB) | Preview

Abstract

Background
Routine psychiatric assessments tailored to older patients are often insufficient to identify the complexity of presentation in younger patients with dementia. Significant overlap between psychiatric disorders and neurodegenerative disease means that high rates of prior incorrect psychiatric diagnosis are common. Long delays to diagnosis, misdiagnosis and lack of knowledge from professionals are key concerns. No specific practice guidelines exist for diagnosis of young-onset dementia (YOD).

Aims
The review evaluates the current evidence about best practice in diagnosis to guide thorough assessment of the complex presentations of YOD with a view to upskilling professionals in the field.

Method
A comprehensive search of the literature adopting a scoping
review methodology was conducted regarding essential elements of diagnosis in YOD, over and above those in current diagnostic criteria for disease subtypes. This methodology was chosen because research in this area is sparse and not amenable to a traditional systematic review.

Results
The quality of evidence identified is variable with the majority provided from expert opinion and evidence is lacking on some topics. Evidence appears weighted towards diagnosis in frontotemporal dementia and its subtypes and young-onset
Alzheimer’s disease.

Conclusions
The literature demonstrates that a clinically rigorous and
systematic approach is necessary in order to avoid mis- or
under diagnosis for younger people. The advent of new disease modifying treatments necessitates clinicians in the field to improve knowledge of new imaging techniques and genetics, with the goal of improving training and practice, and highlights the need for quality indicators and alignment of diagnostic procedures across clinical settings.

Item Type:	Article
Identifier:	10.1192/bjo.2019.36
Additional Information:	© The Royal College of Psychiatrists 2019. This is an Open Accessarticle, distributed under the terms of the Creative CommonsAttribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, andreproduction in any medium, provided the original work isproperly cited. We acknowledge the support of Alzheimer’s Society to The Angela Project (grant ref 278) forwhich this review was prepared. We are grateful for the support of the project from Young Dementia UK, Young DementiaNetwork, Dementia UK UCLH (Biomedical Research Centre).
Keywords:	Young onset dementia; diagnosis; assessment; review; accuracy
Subjects:	Medicine and health
Related URLs:	Author
Depositing User:	Mary O'Malley
Date Deposited:	13 May 2020 10:01
Last Modified:	04 Nov 2024 11:49
URI:	https://repository.uwl.ac.uk/id/eprint/6929

Downloads

Actions (login required)

View Item