Boardman, Dominic A, Smyth, Lesley and Ferreira, Leonardo MR (2025) Editorial: Repurposing cancer immunotherapies for use in autoimmunity and transplantation. Frontiers in Immunology, 16.

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Abstract

Cancer immunotherapy has reshaped modern medicine, providing new hope to patients by mobilizing the immune system to eliminate malignancies with potency and precision. While these therapies were originally designed to enhance immune responses against tumors, recent years have seen a transformative shift in the application of their underlying technology, with many of these pro-inflammatory and cytotoxic tools now being repurposed in a new array of diseases to achieve the opposite effect: immune tolerance. This Research Topic, Repurposing Cancer Immunotherapies for Use in Autoimmunity and Transplantation, brings together a Research Topic of pioneering studies and reviews offering proof-of-concept studies, new mechanistic insights, and translational outlooks on how lessons learned from immuno-oncology are being repurposed to suppress, rather than stimulate, the immune system to establish tolerance in autoimmune disease, organ transplant rejection, graft-vs-host disease, and chronic inflammation

Item Type:	Article
Identifier:	10.3389/fimmu.2025.1690655
Keywords:	cancer immunotherapy, immune tolerance, autoimmune disease, organ transplant rejection, graft-vs-host disease, chronic inflammation, regulatory T cells (Tregs), immune receptor
Subjects:	Medicine and health > Clinical medicine
Date Deposited:	26 Sep 2025 11:02
Last Modified:	26 Sep 2025 11:15
URI:	https://repository.uwl.ac.uk/id/eprint/14105
Sustainable Development Goals:	Goal 3: Good Health and Well-Being

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