Economic evaluation of enhanced cleaning and disinfection of shared medical equipment

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Brain, David, Sivapragasam, Nirmali, Browne, Katrina, White, Nicole M., Russo, Philip L., Cheng, Allen C., Stewardson, Andrew J., Matterson, Georgia, Tehan, Peta E., Graham, Kirsty, Amin, Maham, Kiernan, Martin ORCID: https://orcid.org/0000-0001-9926-7781, King, Jennie and Mitchell, Brett G. (2025) Economic evaluation of enhanced cleaning and disinfection of shared medical equipment. JAMA Network Open, 8 (4). pp. 1-11. ISSN 2574-3805

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Abstract

Importance: The economic value of cleaning and disinfection of shared medical equipment is currently unknown. Objective: To evaluate whether or not better environmental cleaning and disinfection of shared medical equipment would be cost-effective compared with usual care. Design, Setting, and Participants: This economic evaluation study was a within-trial cost-effectiveness analysis of a stepped-wedge cluster randomized clinical trial: the Cleaning and Enhanced Disinfection (CLEEN) study. The trial included 5002 inpatients and was conducted in 10 adult acute-care wards at a tertiary hospital in Australia between March 20, 2023, and November 24, 2023. The evaluation takes a hospital costing perspective. A decision-tree model was developed to evaluate the intervention; costs are presented in Australian dollars. Statistical analysis was performed from May to October 2024. Interventions: A multimodal cleaning intervention was introduced during the intervention, focusing on additional cleaning hours, education, audit, and feedback. The control group received usual care, including routine cleaning by clinical staff. Main Outcomes and Measures: Incremental cost-effectiveness ratio, where the mean change to costs associated with the intervention is divided by the mean change in outcomes. Results: This study assessed 5002 patients (2478 [49.5%] male, 2524 [50.5%] female [50.5%]; mean [SD] age, 71.6 [16.1] years). For a cohort of 1000 patients at risk of health care-associated infection (HAI), the estimated total costs associated with the intervention were $1513300, compared with $2155310 for usual care. The estimated number of HAIs was 100 in the intervention group, compared with 130 for the usual care group. Compared with usual care, the intervention was associated with reduced HAIs and costs, with a 90.5% chance that intervention adoption was cost-saving. This probability increased to 99.9% if a decision-maker was willing to pay $20000 to avoid an infection. Conclusions and Relevance: In this economic evaluation study of enhanced cleaning and disinfection of shared medical equipment, the intervention resulted in reduced HAIs and a $642010 reduction in costs per 1000 patients, compared with the control group. These results suggest that the CLEEN intervention is a cost-saving initiative.

Item Type: Article
Identifier: 10.1001/jamanetworkopen.2025.8565
Keywords: Aged, Australia, Cost-Benefit Analysis, Cross Infection, Disinfection, Female, Humans, Infection Control, Male, Middle Aged, Tertiary Care Centers
Subjects: Medicine and health > Clinical medicine
Depositing User: Martin Kiernan
Date Deposited: 09 May 2025 13:45
Last Modified: 09 May 2025 13:45
URI: https://repository.uwl.ac.uk/id/eprint/13532

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