Trends among pathogens reported as causing bacteraemia in England, 2004-2008

Wilson, Jennie, Elgohari, Suzanne, Livermore, D. M., Cookson, Barry D., Johnson, A., Lamagni, Theresa, Chronias, A. and Sheridan, Elizabeth (2011) Trends among pathogens reported as causing bacteraemia in England, 2004-2008. Clinical Microbiology and Infection, 17 (3). pp. 451-458. ISSN 1198-743X

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Abstract

The Health Protection Agency in England operates a voluntary surveillance system that collects data on bacteraemias reported by over 90% of laboratories in England. Trends in causative microorganisms reported between 2004 and 2008 were analyzed using a generalized linear model with a log link function for Poisson distribution. In 2008, 101 276 episodes of bacteraemia were reported; a rate of 189 per 100 000 population. More than one-half occurred in those aged over 65 years and males. The most common organisms reported were Escherichia coli (23%), coagulase-negative staphylococci (CNS) (16.9%) and Staphylococcus aureus (11.4%). Between 2004 and 2008, E. coli bacteraemia increased by 33% (p <0.001); the species now accounts for more than 30% of bacteraemia in those aged over 75 years. There also were significant increases in bacteraemia caused by other Gram-negative pathogens and marked seasonal variation. Bacteraemia caused by S. aureus increased until 2005, with a decline after 2006 (p <0.001) entirely due to methicillin-resistant strains. CNS bacteraemia have declined significantly since 2007. The renewed dominance of Gram-negative pathogens as major causes of bacteraemia in England is of particular concern because they are associated with a high morbidity and increasing resistance to antibiotics. Further investigation of the underlying causes and prevention strategies is a public health priority. Recent declines in methicillin-resistant S. aureus bacteraemia have not been reflected in other pathogens, including methicillin-susceptible S. aureus.

Item Type: Article
Uncontrolled Keywords: Coagulase-negative staphylococci, Escherichia coli, Staphylococcus aureus, surveillance
Subjects: Medicine and health > Microbiology
Depositing User: Rod Pow
Date Deposited: 12 Sep 2014 11:47
Last Modified: 10 Nov 2017 16:33
URI: http://repository.uwl.ac.uk/id/eprint/934

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