Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources

McGregor, Karen F., Bilek, Nicole, Bennett, Alicia, Kalia, Awdhesh, Beall, Bernard, Carapetis, Jonathan R., Currie, Bart J., Sriprakash, Kadaba S., Spratt, Brian G. and Bessen, Debra E. (2004) Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources. The Journal of Infectious Diseases, 189 (4). pp. 717-723. ISSN 1537-6613

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Abstract

Group A streptococci (GAS) cause several human diseases that differentially affect distinct host populations. Genotypes were defined by multilocus sequence typing and emm typing for 137 organisms collected from individuals in a remote aboriginal island community in tropical Australia and compared with >200 isolates obtained from sources elsewhere in the world. The majority of aboriginal-derived isolates shared emm types and housekeeping alleles with GAS isolates recovered from outside Australia, but these emm types and alleles were in novel combinations. There were many examples in which isolates from aboriginal and non-Australian subjects shared the same emm type, but for ∼50% of emm types, the multilocus genotypes of isolates of the same emm type but from different regions were very different. A single emm type may typically define a single clone within the United States and on the remote island that is the focus of this study, but in many cases, these clones will be different, and this finding has implications for attempts to make global associations between emm types and certain disease manifestations.

Item Type: Article
Uncontrolled Keywords: Group A streptococci (GAS); Multilocus sequence typing; emm typing; Aboriginal Australians
Subjects: Medicine and health > Microbiology
Depositing User: Rod Pow
Date Deposited: 13 Jul 2012 08:30
Last Modified: 25 May 2017 12:45
URI: http://repository.uwl.ac.uk/id/eprint/93

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