Morphometric measurements can improve prediction of progressive vertebral deformity following vertebral damage

Luo, Jin ORCID: https://orcid.org/0000-0001-5451-9535, Dolan, Patricia, Adams, Michael A. and Annesley-Williams, Deborah J. (2021) Morphometric measurements can improve prediction of progressive vertebral deformity following vertebral damage. European Spine Journal. ISSN 0940-6719

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Abstract

Purpose: A damaged vertebral body can exhibit accelerated ‘creep’ under constant load, leading to progressive vertebral deformity. However, the risk of this happening is not easy to predict in clinical practice. The present cadaveric study aimed to identify morphometric measurements in a damaged vertebral body that can predict a susceptibility to accelerated creep.
Methods: 27 vertebral trabeculae samples cored from five cadaveric spines (3 male, 2 female, aged 36 to 73 (mean 57) yrs) were mechanically tested to establish the relationship between bone damage and residual strain. Compression testing of 28 human spinal motion segments (three vertebrae and intervening soft tissues) dissected from 14 cadaveric spines (10 male, 4 female, aged 67 to 92 (mean 80) yrs) showed how the rate of creep of a damaged vertebral body increases with increasing “damage intensity” in its trabecular bone. Damage intensity was calculated from vertebral body residual strain following initial compressive overload using the relationship established in the compression test of trabecular bone samples.
Results: Calculations from trabecular bone samples showed a strong non-linear relationship between residual strain and trabecular bone damage intensity (R2 = 0.78, P < 0.001). In damaged vertebral bodies, damage intensity was then related to vertebral creep rate (R2 = 0.39, P = 0.001). This procedure enabled accelerated vertebral body creep to be predicted from morphological changes (residual strains) in the damaged vertebra.
Conclusion: These findings suggest that morphometric measurements obtained from fractured vertebrae can be used to quantify vertebral damage and hence to predict progressive vertebral deformity.

Item Type: Article
Additional Information: Copyright © 2021, The Author(s), under exclusive licence to Springer
Uncontrolled Keywords: Clinical imaging; Creep; Deformity; Residual strain; Vertebral damage; Vertebral morphometry.
Subjects: Construction and engineering > Biomedical engineering
Medicine and health > Clinical medicine
Related URLs:
Depositing User: Jin Luo
Date Deposited: 07 Oct 2021 12:05
Last Modified: 07 Oct 2021 15:05
URI: http://repository.uwl.ac.uk/id/eprint/8309

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