Feng, MH, Li, ZX, Wang, Q, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Li, YJ, Li, SY, Xu, W and Xiang, HB (2020) Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis. Aging, 13 (2). pp. 2294-2309.

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Abstract

Background: Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown.
Methods: Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS).
Results: Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem.
Conclusions: Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These studies may contribute to our understanding of metabolic mechanisms underlying myocardial ischemia-reperfusion injury in rats.

Item Type:	Article
Additional Information:	Copyright: © 2020 Feng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords:	myocardial ischemia-reperfusion injury; proton nuclear magnetic spectroscopy; thalamus; brainstem
Subjects:	Medicine and health > Clinical medicine
Related URLs:	Publisher
Depositing User:	Anne Manyande
Date Deposited:	30 Nov 2020 18:41
Last Modified:	05 Feb 2021 15:16
URI:	http://repository.uwl.ac.uk/id/eprint/7501

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