Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Feng, MH, Li, ZX, Wang, Q, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Li, YJ, Li, SY, Xu, W and Xiang, HB (2020) Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis. Aging. (In Press)

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Abstract

Background: Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown.
Methods: Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS).
Results: Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem.
Conclusions: Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These studies may contribute to our understanding of metabolic mechanisms underlying myocardial ischemia-reperfusion injury in rats.

Item Type: Article
Uncontrolled Keywords: myocardial ischemia-reperfusion injury; proton nuclear magnetic spectroscopy; thalamus; brainstem
Subjects: Medicine and health > Clinical medicine
Related URLs:
Depositing User: Anne Manyande
Date Deposited: 30 Nov 2020 18:41
Last Modified: 30 Nov 2020 21:56
URI: http://repository.uwl.ac.uk/id/eprint/7501

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