Investigation of robust visual reaction and functional connectivity in the rat brain induced by rocuronium bromide with functional MRI

Zhou, Wenchang, Cai, Aoling, Nie, Binbin, Wen, Zhang, Yang, Ting, Zheng, Ning, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Wang, Xuxia, Xu, Fuqiang, Tian, Xuebi and Wang, Jie (2020) Investigation of robust visual reaction and functional connectivity in the rat brain induced by rocuronium bromide with functional MRI. American Journal of Translational Research, 12 (6). pp. 2396-2408. ISSN 1943-8141

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Abstract

Functional magnetic resonance imaging (fMRI) has been used extensively to understand the brain function of a wide range of neurological and psychiatric disorders. When applied to animal studies, anesthesia is always used to reduce the movement of the animal and also reduce the impacts on the results of fMRI. Several awake models have been proposed by applying physical animal movement restrictions. However, restraining devices were designed for individual subject which limits the promotion of fMRI in awake animals. Here, a clinical muscle relaxant rocuronium bromide (RB) was introduced to restrain the animal in fMRI scanning time. The fMRI reactions of the animal induced with RB and the other two commonly used anesthesia protocols were investigated. The results of the fMRI showed that there were increased functional connectivity and well-round visual responses in the RB induced state. Furthermore, significant BOLD signal changes were found in the cortex and thalamus regions when the animal revived from isoflurane, which should be essential to further understand the effects of anesthesia on the brain.
Keywords: Rocuronium bromide, isoflurane, animal anesthesia, fMRI, visual stimulation, resting state

Item Type: Article
Uncontrolled Keywords: Rocuronium bromide, isoflurane, animal anesthesia, fMRI, visual stimulation, resting state
Subjects: Medicine and health > Clinical medicine > Therapeutics
Related URLs:
Depositing User: Anne Manyande
Date Deposited: 28 Jul 2020 14:18
Last Modified: 28 Jul 2020 17:54
URI: http://repository.uwl.ac.uk/id/eprint/7211

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