Src-family protein tyrosine kinases: a promising target for treating chronic pain

Ge, Meng-Meng, Zhou, Ya-Qun, Tian, Xue-Bi, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Tian, Yu-Ke, Ye, Da-Wei and Yang, Hui (2020) Src-family protein tyrosine kinases: a promising target for treating chronic pain. Biomedicine & Pharmacotherapy, 125. ISSN 0753-3322

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Abstract

Abstract
Despite growing knowledge of the mechanisms of chronic pain, it remains a major challenge facing clinical practice. Src-family protein tyrosine kinases (SFKs), a group of non-receptor protein tyrosine kinases, have been implicated in neuronal development and synaptic plasticity. SFKs are critically central to various transmembrane receptors e.g. G-protein coupled receptor (GPCR), EphB receptor (EphBR), increased intracellular calcium, epidermal growth factor (EGF) and other growth factors that regulate the phosphorylation of N-methyl-D-aspartic acid receptor (NMDAR) 2B subunit, thus contributing to the development of chronic pain. SFKs have also been regarded as an important point of convergence of intracellular signaling components that regulate microglia functions and the immune response. Additionally, intrathecal administration of SFKs inhibitors significantly alleviates mechanical allodynia in different chronic pain models. Thus, here we reviewed the current evidence of the role of SFKs in the development of chronic pain caused by complete Freund's adjuvant (CFA) injection, peripheral nerve injury (PNI), streptozotocin (STZ) injection and bone metastasis. Moreover, the role of SFKs on the development of morphine tolerance has also been discussed. Management of SFKs therefore emerged as a potential therapeutic target for the treatment of chronic pain in terms of safety and efficacy.

Key words
Chronic pain; Src-family protein tyrosine kinases; N-methyl-D-aspartic acid receptor; Microglia.

Item Type: Article
Uncontrolled Keywords: Chronic pain; Src-family protein tyrosine kinases; N-methyl-D-aspartic acid receptor; Microglia
Subjects: Medicine and health > Clinical medicine > Therapeutics
Medicine and health > Clinical medicine
Medicine and health
Depositing User: Anne Manyande
Date Deposited: 26 Feb 2020 13:21
Last Modified: 10 Mar 2020 13:52
URI: http://repository.uwl.ac.uk/id/eprint/6775

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