Cell-type-specific whole-brain direct inputs to the anterior and posterior piriform cortex

Wang, L., Zhang, Z., Chen, J., Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Haddad, R., Liu, Q. and Zu, F. (2020) Cell-type-specific whole-brain direct inputs to the anterior and posterior piriform cortex. Frontiers In Neural Circuits, 14. p. 4.

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Abstract

The piriform cortex (PC) is a key region in the brain that is involved in both processing and coding of olfactory information. It is implicated in various brain disorders, such as epilepsy, Alzheimer’s disease and autism. The PC consists of anterior (APC) and posterior (PPC) parts, which are largely different both in their anatomy and functions. However, the monosynaptic input networks to specific neural populations within APC and PPC remain poorly understood. Here, we mapped the whole-brain monosynaptic inputs to the two major neural populations, the excitatory glutamatergic principal neurons and the inhibitory γ-aminobutyric acid (GABA)-ergic interneurons within the APC and PPC using the rabies virus-mediated retrograde trans-synaptic tracing system. We found that for both types of neurons, APC and PPC share some similarities in input networks, with dominant inputs originating from the olfactory areas (OLF), followed by the isocortex, hippocampal formation (HPF), cortical subplate (CTXsp), cerebral nuclei (CNU) and interbrain (IB), whereas the midbrain (MB) and hindbrain (HB) were either blank or sporadically labeled. However, APC and PPC also showed distinct features in their input distribution patterns. For both types of neurons, the APC was innervated more heavily by bilateral OLF and cortical areas compared to the PPC; whereas the input proportions from the HPF to the PPC were higher than to the APC. Overall, our results revealed that monosynaptic input networks to both excitatory and inhibitory neural populations of different PC subdivisions, may provide the structural architecture for revealing the diverse functions of the PC.

Item Type: Article
Uncontrolled Keywords: anterior piriform cortex, posterior piriform cortex, monosynaptic inputs, glutamatergic neurons, GABAergic neurons
Subjects: Medicine and health > Microbiology
Medicine and health
Depositing User: Anne Manyande
Date Deposited: 22 Jan 2020 12:06
Last Modified: 11 Feb 2020 14:34
URI: http://repository.uwl.ac.uk/id/eprint/6698

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