PI3K/Akt pathway: a potential therapeutic target for chronic pain

Chen, Shu-Ping, Zhou, Ya-Qun, Liu, Dai-Qiang, Zhang, Wen, Manyande, Anne, Guan, Xue-Hai, Tian, Yu-Ke, Ye, Da-Wei and Omar, Deeq Mohamed (2017) PI3K/Akt pathway: a potential therapeutic target for chronic pain. Current Pharmaceutical Design, 23 (12). pp. 1860-1868. ISSN 1381-6128

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Abstract

Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and Aδ fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of PI3K/Akt pathway in the progression of chronic pain through sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia.

Item Type: Article
Additional Information: The published manuscript is available at EurekaSelect via https://doi.org/10.2174/1381612823666170210150147.
Uncontrolled Keywords: PI3K, Akt, chronic pain
Subjects: Medicine and health
Psychology
Depositing User: Anne Manyande
Date Deposited: 06 Mar 2017 11:23
Last Modified: 09 Oct 2017 09:05
URI: http://repository.uwl.ac.uk/id/eprint/3214

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