Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy

Brew, Obed and Sullivan, Mark H.F. (2001) Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. Inflammation Research, 50 (9). pp. 449-452. ISSN 1023-3830

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Abstract

OBJECTIVE AND DESIGN

To localise mRNAs for the histamine receptors H1, H2 and H3, and for diamine oxidase, in the placenta and decidua of the human feto-maternal interface.

MATERIALS AND METHODS

Complementary DNA for each mRNA of interest was amplified by polymerase chain reaction. Sub-cloned sequences were used to prepare probes for in situ hybridisation, and these were employed to localise the expression of mRNAs for histamine receptors H1 and H2, and for diamine oxidase.

RESULTS

mRNA for histamine receptors H1 and H2, and for diamine oxidase could be detected at the feto-maternal interface of human pregnancy, and localised to both decidual and placental cells.

CONCLUSION

The co-expression of these receptors and DAO is consistent with a role for histamine at the feto-maternal interface of human pregnancy.

Item Type: Article
Subjects: Medicine and health
Depositing User: Obed Brew
Date Deposited: 01 Jun 2016 18:25
Last Modified: 31 Oct 2017 15:10
URI: http://repository.uwl.ac.uk/id/eprint/2326

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