Placental gene expression in response to histamine and oxygen

Brew, Obed and Sullivan, Mark H.F. (2016) Placental gene expression in response to histamine and oxygen. [Dataset]

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Abstract

Maternal Blood histamine level is tightly controlled in normal pregnancy. However, in specific complications of human pregnancy such as pre-eclampsia the levels of both placental and maternal blood histamine increase. Increasing blood histamine levels nonetheless, have been associated with oxidative stress, endothelial dysfunction, abnormal tissue growth, and Th1/TH2 imbalance, which are also linked to pre-eclampsia. Little is known of the molecular responses in the placenta to the prolonged exposure to increasing histamine levels in the presence of changing oxygen concentrations.
We used microarray to detail the global programme of placental gene expression in response to histamine and oxygen and identified distinct classes of regulated genes underlying the molecular functions of histamine in the placenta.

Item Type: Dataset
Subjects: Medicine and health
Depositing User: Obed Brew
Date Deposited: 13 Jun 2016 19:24
Last Modified: 18 Jan 2017 15:14
URI: http://repository.uwl.ac.uk/id/eprint/2551

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