El-Deeb, Wael, Iacob, Olimpia, Fayez, Mahmoud, Elsohaby, Ibrahim, Alhaider, Abdulrahman, Mkrtchyan, Hermine, Ibrahim, Abdelazim and Alhumam, Naser (2022) Assessment of the immune response of clinically infected calves to Cryptosporidium parvum infection. Agriculture, 12 (8). e1151.
Preview |
PDF
El-Deeb_et_al._2022_agriculture._Assessment_of_the_immune_response_of_clinically_infected_calves_to_Cryptosporidium_parvum_infection.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Cryptosporidium parvum (C. parvum) infection is one of the main causes of diarrhea in calves. The current study assessed the role of blood biomarkers (acute-phase proteins (APPs), procalcitonin, neopterin, cytokines, and oxidative stress in the pathogenesis, diagnosis, and prognosis of calves naturally infected with C. parvum. Fifty-seven calves, aged from 10 to 45 days, were detected positive for C. parvum and were allotted into the diseased group; twenty healthy calves were selected as a control group. Serum amyloid A, haptoglobin, cytokines, neopterin, procalcitonin, and stress biomarkers were tested in the diseased and healthy groups. The serum levels of APPs, cytokines, neopterin, procalcitonin, and malondialdehyde increased, whereas antioxidant levels were significantly decreased in diseased calves compared to the healthy group. Moreover, all examined biomarkers were significantly altered towards normal values in infected calves following different treatment protocols. All biomarkers examined were highly effective in discriminating between C. parvum-infected calves and healthy individuals. Furthermore, the area under the curve (AUC) showed that all tested parameters had a higher degree of prognostic accuracy in predicting the treatment response of calves naturally infected with C. parvum. Our data suggest the usefulness of the examined biomarkers in the immune pathogenesis of the C. parvum infection in calves, contributing to diagnosis and treatment efficacy.
Item Type: | Article |
---|---|
Identifier: | 10.3390/agriculture12081151 |
Additional Information: | Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
Keywords: | procalcitonin, neopterin, cytokines, Cryptosporidium, haptoglobin, malondialdehyde |
Subjects: | Medicine and health |
Related URLs: | |
SWORD Depositor: | Jisc Router |
Depositing User: | Hermine Mkrtchyan |
Date Deposited: | 22 Aug 2022 12:11 |
Last Modified: | 19 Sep 2024 09:45 |
URI: | https://repository.uwl.ac.uk/id/eprint/9292 |
Downloads
Downloads per month over past year
Actions (login required)
View Item |