Brain imaging changes in patients recovered from COVID-19: a narrative review

Huang, Yan, Ling, Qiong, Manyande, Anne ORCID:, Wu, Duozhi and Xiang, Boqi (2022) Brain imaging changes in patients recovered from COVID-19: a narrative review. Frontiers in Neuroscience, 16. p. 855868. ISSN 1662-4548

Huang et al (2022) Research progress of brain imaging changes in patients recovered from COVID-19.pdf - Published Version
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The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused several outbreaks of highly contagious respiratory diseases worldwide. The respiratory symptoms of Coronavirus Disease-19 (COVID-19) have been closely monitored and studied, while the central nervous system (CNS) and peripheral system (PNS) lesions induced by COVID-19 have not received much attention. Currently, patients with COVID-19-associated encephalopathy present with dizziness, headache, anxiety and depression, stroke, epileptic seizures, the Guillain-Barre syndrome (GBS), and demyelinating disease. The exact pathologic basis for these neurological symptoms is currently not known. Rapid mutation of the SARS-CoV-2 genome leads to the appearance of SARS-CoV-2 variants of concern (VOCs), which have higher infectivity and virulence. Therefore, this narrative review will focus on the imaging assessment of COVID-19 and its VOC. There has been an increase in technologies, such as [18F]fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and functional magnetic resonance imaging (fMRI), that have been used to observe changes in brain microstructure over time in patients with COVID-19 recovery. Medical imaging and pathological approaches aimed at exploring the associations between COVID-19 and its VOC, with cranial nerve and abnormal nerve discharge will shed light on the rehabilitation process of brain microstructural changes related to SARS-CoV-2, and aid future research in our understanding of the treatment and prognosis of COVID-19 encephalopathy.

Item Type: Article
Identifier: 10.3389/fnins.2022.855868
Additional Information: © 2022 Huang, Ling, Manyande, Wu and Xiang. This is the final form version of the following article: [Huang Y, Ling Q, Manyande A, Wu D and Xiang B (2022) Brain Imaging Changes in Patients Recovered From COVID-19: A Narrative Review. Front. Neurosci. 16:855868. doi: 10.3389/fnins.2022.855868], which was first published by Frontiers Media at
Keywords: SARS-CoV-2, COVID-19, COVID-19 variants of concern, magnetic resonance imaging, brain imaging
Subjects: Medicine and health > Health promotion and public health
Medicine and health > Health promotion and public health > Infection prevention
Medicine and health
Related URLs:
Depositing User: Anne Manyande
Date Deposited: 12 Apr 2022 14:07
Last Modified: 23 Aug 2022 08:37


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