PI3K/Akt pathway: a potential therapeutic target for chronic pain

Chen, Shu-Ping, Zhou, Ya-Qun, Liu, Dai-Qiang, Zhang, Wen, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Guan, Xue-Hai, Tian, Yu-Ke, Ye, Da-Wei and Omar, Deeq Mohamed (2017) PI3K/Akt pathway: a potential therapeutic target for chronic pain. Current Pharmaceutical Design, 23 (12). pp. 1860-1868. ISSN 1381-6128

PI3KAkt pathway - a potential therapeutic target for chronic pain.pdf - Accepted Version

Download (477kB) | Preview


Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and Aδ fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of PI3K/Akt pathway in the progression of chronic pain through sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia.

Item Type: Article
Identifier: 10.2174/1381612823666170210150147
Additional Information: The published manuscript is available at EurekaSelect via https://doi.org/10.2174/1381612823666170210150147.
Keywords: PI3K, Akt, chronic pain
Subjects: Medicine and health
Depositing User: Anne Manyande
Date Deposited: 06 Mar 2017 11:23
Last Modified: 28 Aug 2021 07:22
URI: https://repository.uwl.ac.uk/id/eprint/3214


Downloads per month over past year

Actions (login required)

View Item View Item