Li, J, Li, Z, Liu, Y, Li, Y, Wu, Y, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Li, Z and Xiang, H (2024) Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets. iScience, 27 (12). p. 111274.

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Abstract

Abstract
The pathogenesis of hyperalgesia is complex and can lead to poor clinical treatment.
Our study revealed that epididymal white adipose tissue (eWAT) from SNI mice is involved in the occurrence of hyperalgesia after adipose tissue transplantation.
We also showed that lysophosphatidylcholine (LPC) is enriched in the eWAT of SNI mice using non-targeted metabolomic analysis and verified that the levels of LPC
in plasma and the anterior cingulate cortex (ACC) region increased following eWAT transplantation.
Based on the immunohistochemistry results, we observed that LPC in the ACC region activated microglia via the TRPV1/CamkⅡ pathway.
In turn, the activated microglia triggered the degradation of perineuronal nets (PNNs) in the ACC region,
disrupted its barrier role and led to the destruction of parvalbumin-positive (PV+) neurons and inhibitory interneuron dysfunction.
These findings elucidate the mechanism underlying hyperalgesia from the perspective of lipid metabolite LPC and PNNs and provide potential new strategies for the treatment of hyperalgesia.
Keywords: Fat transplantation; Hyperalgesia; Anterior cingulate cortex; Perineuronal nets; Lysophosphatidylcholine

Item Type:	Article
Identifier:	10.1016/j.isci.2024.111274
Subjects:	Natural sciences > Cell and molecular biology
Depositing User:	Anne Manyande
Date Deposited:	28 Oct 2024 08:46
Last Modified:	22 Nov 2024 09:45
URI:	https://repository.uwl.ac.uk/id/eprint/12805

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