Bravo-Santano, Natalia, Behrends, Volker ORCID: https://orcid.org/0000-0003-4855-5497 and Letek, Michal (2019) Host-targeted therapeutics against multidrug resistant intracellular Staphylococcus aureus. Antibiotics, 8 (4). p. 241.

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Abstract

Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of human cells. S. aureus has shown to rapidly overcome traditional antibiotherapy by developing multidrug resistance. Furthermore, intracellular S. aureus is protected from the last-resort antibiotics—vancomycin, daptomycin, and linezolid—as they are unable to achieve plasma concentrations sufficient for intracellular killing. Therefore, there is an urgent need to develop novel anti-infective therapies against S. aureus infections. Here, we review the current state of the field and highlight the exploitation of host-directed approaches as a promising strategy going forward.

Item Type:	Article
Identifier:	10.3390/antibiotics8040241
Subjects:	Medicine and health
Depositing User:	Marc Forster
Date Deposited:	12 Apr 2024 09:16
Last Modified:	12 Apr 2024 09:16
URI:	https://repository.uwl.ac.uk/id/eprint/11479

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