Williams, Huw D, Behrends, Volker, Bundy, Jacob G, Ryall, Ben and Zlosnik, James E (2010) Hypertonic saline therapy in cystic fibrosis: do population shifts caused by the osmotic sensitivity of infecting bacteria explain the effectiveness of this treatment? Frontiers in microbiology, 1 (120). p. 7262.

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Abstract

Cystic fibrosis (CF) is caused by a defect in the CF transmembrane regulator that leads to depletion and dehydration of the airway surface liquid (ASL) of the lung epithelium, providing an environment that can be infected by bacteria leading to increased morbidity and mortality. Pseudomonas aeruginosa chronically infects more than 80% of CF patients and one hallmark of infection is the emergence of a mucoid phenotype associated with a worsening prognosis and more rapid decline in lung function. Hypertonic saline (HS) is a clinically proven treatment that improves mucociliary clearance through partial rehydration of the ASL of the lung. Strikingly,
while HS therapy does not alter the prevalence of P. aeruginosa in the CF lung it does decrease
the frequency of episodes of acute, severe illness known as infective exacerbations among CF patients. In this article, we propose a hypothesis whereby the positive clinical effects of HS treatment are explained by the osmotic sensitivity of the mucoid sub-population of P. aeruginosa
in the CF lung leading to selection against this group in favor of the osmotically resistant non�mucoid variants.

Item Type:	Article
Keywords:	mucoid, mucA, alginate, infective exacerbation, Pseudomonas aeruginosa, metabolomics
Subjects:	Natural sciences > Cell and molecular biology Natural sciences
Depositing User:	Volker Behrends
Date Deposited:	29 Apr 2024 10:47
Last Modified:	04 Nov 2024 11:34
URI:	https://repository.uwl.ac.uk/id/eprint/11453

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