Zhu, Jinpiao, Chen, Chang, Wu, Jinfeng and Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722 (2023) Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats. British Journal of Anaesthesia, 131. pp. 531-541.

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Abstract

Background
Sleep disorders can profoundly affect neurological function. We investigated changes in social and anxiety-related brain functional connectivity induced by sleep deprivation, and the potential therapeutic effects of the general anaesthetics propofol and sevoflurane in rats.
Methods
Twelve-week-old male Sprague–Dawley rats were subjected to sleep deprivation for 20 h per day (from 14:00 to 10:00 the next day) for 4 consecutive weeks. They were free from sleep deprivation for the remaining 4 h during which they received propofol (40 mg kg–1 i.p.) or sevoflurane (2% for 2 h) per day or no treatment. These cohorts were instrumented for EEG/EMG recordings on days 2, 14, and 28. Different cohorts were used for open field and three-chambered social behavioural tests, functional MRI, nuclear magnetic resonance spectroscopy, and positron emission tomography imaging 48 h after 4 weeks of sleep deprivation.
Results
Propofol protected against sleep deprivation-induced anxiety behaviours with more time (44.7 [8.9] s vs 24.2 [4.1] s for the sleep-deprivation controls; P<0.001) spent in the central area of the open field test and improved social preference index by 30% (all P<0.01). Compared with the sleep-deprived rats, propofol treatment enhanced overall functional connectivity by 74% (P<0.05) and overall glucose metabolism by 30% (P<0.01), and improved glutamate kinetics by 20% (P<0.05). In contrast, these effects were not found after sevoflurane treatment.
Conclusions
Unlike sevoflurane, propofol reduced sleep deprivation-induced social and anxiety-related behaviours. Propofol might be superior to sevoflurane for patients with sleep disorders who receive anaesthesia, which should be studied in clinical studies.

Item Type:	Article
Identifier:	10.1016/j.bja.2023.05.025
Subjects:	Medicine and health
Depositing User:	Marc Forster
Date Deposited:	11 Apr 2024 08:30
Last Modified:	11 Apr 2024 08:30
URI:	https://repository.uwl.ac.uk/id/eprint/11433

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