Tianning, Sun, Feng, Maohui, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Xiang, Hong-bing, Xiong, Jun and He, Zhigang (2023) Regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract and MRI research progress: a literature review. Frontiers in Neuroscience, 17.

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Abstract

Patients with liver disease are prone to various cognitive impairments. It is undeniable that cognitive impairment is often regulated by both the nervous system and the immune system. In this review our research focused on the regulation of mild cognitive impairment associated with liver disease by humoral factors derived from the gastrointestinal tract, and revealed that its mechanisms may be involved with hyperammonemia, neuroinflammation, brain energy and neurotransmitter metabolic disorders, and liver-derived factors. In addition, we share the emerging research progress in magnetic resonance imaging techniques of the brain during mild cognitive impairment associated with liver disease, in order to provide ideas for the prevention and treatment of mild cognitive impairment in liver disease.

Item Type:	Article
Identifier:	10.3389/fnins.2023.1206417
Keywords:	cognitive impairment, liver disease, humoral factor, MRI research, brain
Subjects:	Medicine and health
Related URLs:	Publisher
Date Deposited:	30 May 2023
Dates:	Date Publication status 30 May 2023 Accepted 16 June 2023 Published
School, department or research centre:	School of Human and Social Sciences
Keywords:	cognitive impairment, liver disease, humoral factor, MRI research, brain
URI:	https://repository.uwl.ac.uk/id/eprint/10017

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