Influence of Cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats

Mirza, Khalid, Alenda, Andrea, Eftekhar, Amir, Grossman, Nir, Nikolic, Konstantin ORCID: https://orcid.org/0000-0002-6551-2977, Bloom, Stephen and Toumazou, Christofer (2018) Influence of Cholecystokinin-8 on compound nerve action potentials from ventral gastric vagus in rats. International Journal of Neural Systems, 28 (9). p. 1850006. ISSN 0129-0657

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Abstract

Objective: Vagus Nerve Stimulation (VNS) has shown great promise as a potential therapy for a number of conditions, such as epilepsy, depression and for Neurometabolic Therapies, especially for treating obesity. The objective of this study was to characterize the left ventral subdiaphragmatic gastric trunk of vagus nerve (SubDiaGVN) and to analyze the influence of intravenous injection of gut hormone cholecystokinin octapeptide (CCK-8) on compound nerve action potential (CNAP) observed on the same branch, with the aim of understanding the impact of hormones on VNS and incorporating the methods and results into closed loop implant design. Methods: The cervical region of the left vagus nerve (CerVN) of male Wistar rats was stimulated with electric current and the elicited CNAPs were recorded on the SubDiaGVN under four different conditions: Control (no injection), Saline, CCK1 (100pmol/kg) and CCK2 (1000pmol/kg) injections. Results: We identified the presence of A

Item Type: Article
Uncontrolled Keywords: Compound nerve action potentials; subdiaphragmatic vagus nerve; vagus nerve stimulation; closed loop system
Subjects: Construction and engineering > Biomedical engineering
Related URLs:
Depositing User: Konstantin Nikolic
Date Deposited: 15 Jun 2021 12:53
Last Modified: 28 Aug 2021 07:15
URI: http://repository.uwl.ac.uk/id/eprint/7967

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