Integration of urinary EN2 protein & cell-free RNA data in the development of a multivariable risk model for the detection of prostate cancer prior to biopsy

Connell, Shea, Mills, Robert, Pandha, Hardev, Morgan, Richard ORCID: https://orcid.org/0000-0002-8721-4479, Cooper, Colin, Clark, Jeremy and Brewer, Daniel (2021) Integration of urinary EN2 protein & cell-free RNA data in the development of a multivariable risk model for the detection of prostate cancer prior to biopsy. Cancers, 13 (9). p. 2102.

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Abstract

Prostate cancer is a disease responsible for a large proportion of all male cancer deaths but there is a high chance that a patient will die with the disease rather than from. Therefore, there is a desperate need for improvements in diagnosing and predicting outcomes for prostate cancer patients to minimise overdiagnosis and overtreatment whilst appropriately treating men with aggressive disease, especially if this can be done without taking an invasive biopsy. In this work we develop a test that predicts whether a patient has prostate cancer and how aggressive the disease is from a urine sample. This model combines the measurement of a protein-marker called EN2 and the levels of 10 genes measured in urine and proves that integration of information from multiple, non-invasive biomarker sources has the potential to greatly improve how patients with a clinical suspicion of prostate cancer are risk-assessed prior to an invasive biopsy.

Item Type: Article
Additional Information: This research was funded by Movember Foundation GAP1 Urine Biomarker project, The Masonic Charitable Foundation, The Bob Champion Cancer Trust, the King family, The Andy Ripley Memorial Fund and the Stephen Hargrave Trust.
Uncontrolled Keywords: prostate cancer; biomarker; urine; machine learning; TRIPOD; liquid biopsy
Subjects: Natural sciences > Cell and molecular biology
Related URLs:
Depositing User: Richard Morgan
Date Deposited: 04 May 2021 11:29
Last Modified: 28 Aug 2021 07:15
URI: http://repository.uwl.ac.uk/id/eprint/7842

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