HOX transcription factors and the prostate tumor microenvironment

Morgan, Richard ORCID: https://orcid.org/0000-0002-8721-4479 and Pandha, Hardev (2017) HOX transcription factors and the prostate tumor microenvironment. Journal of Cancer Metastasis and Treatment, 3 (12). pp. 278-287. ISSN 2394-4722

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It is now well established that the tumor microenvironment plays an essential role in the survival, growth, invasion, and spread of cancer through the regulation of angiogenesis and localized immune responses. This review examines the role of the HOX genes, which encode a family of homeodomain-containing transcription factors, in the interaction between prostate tumors and their microenvironment. Previous studies have established that HOX genes have an important function in prostate cancer cell survival in vitro and in vivo, but there is also evidence that HOX proteins regulate the expression of genes in the cancer cell that influence the tumor microenvironment, and that cells in the microenvironment likewise express HOX genes that confer a tumor-supportive function. Here we provide an overview of these studies that, taken together, indicate that the HOX genes help mediate cross talk between prostate tumors and their microenvironment.

Item Type: Article
Identifier: 10.20517/2394-4722.2017.31
Keywords: Prostate cancer, tumor microenvironment, HOX, PBX, metastasis, angiogenesis
Subjects: Natural sciences > Cell and molecular biology
Related URLs:
Depositing User: Richard Morgan
Date Deposited: 09 Jul 2020 08:42
Last Modified: 06 Feb 2024 16:03
URI: https://repository.uwl.ac.uk/id/eprint/7171


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