Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction of neuropathic pain in rats

Xiong, Bingrui, Zhang, Wen, Zhang, Longqing, Huang, Xian, Zhou, Wenchang, Zou, Qian, Manyande, Anne ORCID: https://orcid.org/0000-0002-8257-0722, Wang, Jie, Tian, Yuke and Tian, Xuebi (2020) Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction of neuropathic pain in rats. Pain. ISSN 0304-3959

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Manyande_etal_PAIN_2020_Hippocampal_glutamatergic_synapses_impairment_mediated_novel-object_recognition_dysfunction_of_neuropathic_pain_in_rats.pdf - Accepted Version

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Cognitive impairment is one of the most common complications associated with chronic pain. Almost 20% of chronic pain patients suffer from cognitive impairment, which may substantially influence their quality of life. Levels of major excitatory neurotransmitters in the central nervous system, and alterations in the glutamatergic system may influence cognitive function and the pain sensory pathway. In the present study, we adopted the spare nerve injury model to establish the progress of chronic pain and investigated the mechanism underlying the cognitive aspect related to it. At behavioral level, using the novel-object recognition test, mechanical hypersensitivity was observed in peripheral nerve injured rats as they exhibited recognition deficits. We showed a dramatic decrease in hippocampal glutamate concentration using nuclear magnetic resonance and reduced glutamatergic synaptic transmission using whole-cell recordings. These were associated with deficient hippocampal long-term potentiation induced by high-frequency stimulation of the Schaffer collateral afferent. Ultra-high performance liquid chromatography revealed lower levels of D-serine in the hippocampus of SNI rats and that D-serine treatment could restore synaptic plasticity and cognitive dysfunction. The reduction of excitatory synapses was also increased by administering D-serine. These findings suggest that chronic pain has a critical effect on synaptic plasticity linked to cognitive function and may built up a new target for the development of cognitive impairment under chronic pain conditions.

Item Type: Article
Identifier: 10.1097/j.pain.0000000000001878
Keywords: Neuropathic pain, hippocampus, cognitive impairment, glutamatergic synaptic transmission, D-serine
Subjects: Psychology
SWORD Depositor: Jisc Router
Depositing User: Jisc Router
Date Deposited: 30 Apr 2020 16:27
Last Modified: 06 Feb 2024 16:02
URI: https://repository.uwl.ac.uk/id/eprint/6855


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