Pratt, Robert, Loveday, Heather, Pellowe, C. M., Robinson, Nicola, Franks, Peter J., Hankins, Matthew and Loveday, Clive (2001) Adherence to antiretroviral therapy - appropriate use of self reporting in clinical practice. HIV Clinical Trials, 2 (2). pp. 146-159. ISSN 1528-4336Full text not available from this repository.
This study investigated the factors that may affect adherence to antiretroviral therapy in people with HIV infection and compared the use of three self-report tools to determine client adherence.
A descriptive, cross-sectional study of 260 HIV-infected clients attending nine HIV outpatient centers in England was conducted using researcher-administered instruments. Self-reports of adherence were assessed using the Morisky Medication Adherence Scale (MMAS), Reported Adherence to Medication Scale (RAM), and the Patient Adjustment to Medication Scale (PAM).
Univariate analysis of clients' self-reports indicated a number of associations with adherence. Significant associations with less adherent behavior identified by two or more self-report tools were the reported use of recreational drugs, p = .001; living alone, p = .041; feeling depressed, p = .02; being influenced by the media, p = .037; and lack of a close confidant, p = .037. Greater adherence was associated with clients reporting a positive mental attitude to HIV infection, p = .038. Principal component analysis (PCA) of each self-report tool identified two well-recognized constructs: intentional nonadherence and nonintentional nonadherence. In addition, a third construct of following instructions was identified from PAM, a scale developed by the authors. Subsequent regression analysis failed to confirm the associations with adherence suggested by the univariate analysis.
This study suggests that the design and use of self-report tools to identify client's adherence to complex antiretroviral regimens may need to measure individual constructs of adherence to accurately assess adherence behavior.
|Uncontrolled Keywords:||HIV infection; Antiretroviral therapy; Self-report tools; Morisky Medication Adherence Scale (MMAS); Reported Adherence to Medication Scale (RAM); Patient Adjustment to Medication Scale (PAM).|
|Subjects:||Medicine and health > Clinical medicine|
|Depositing User:||ROD POW|
|Date Deposited:||06 Jul 2012 09:18|
|Last Modified:||12 Jan 2017 10:03|
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