Evaluation of the accuracy of capillary hydroxybutyrate measurement compared with other measurements in the diagnosis of diabetic ketoacidosis: a systematic review

Brooke, Joanne, Stiell, Marlon and Ojo, Omorogieva (2016) Evaluation of the accuracy of capillary hydroxybutyrate measurement compared with other measurements in the diagnosis of diabetic ketoacidosis: a systematic review. International Journal of Environmental Research and Public Health, 13 (9). p. 837. ISSN 1660-4601

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Abstract

A complication of diabetes is diabetic ketoacidosis (DKA), which if left untreated is a life threatening condition. Prompt and accurate diagnosis of DKA is required for the commencement of life saving interventions. Measurements of ketone bodies in DKA have usually been through nitroprusside urine acetoacetate testing. The aim of this systematic review was to examine whether capillary β-hydroxybutyrate (β-OHB) testing is more accurate compared to other diagnostic methods of DKA. The following electronic databases were searched: EBSCO Host, MEDLINE, PSYCHInfo, CINAHL and Science Direct for publications from 1 January 2005 and up to and including 1 January 2016. Inclusion criteria were: Adults 18 years and over and known type 1 or type 2 diabetes. Retrospective and prospective observation studies were included. A total of nine studies met the inclusion criteria. Capillary β-OHB was found to have high sensitivity, specificity, positive predictive value and negative predictive value in identifying DKA compared to urinary ketone testing.

Item Type: Article
Additional Information: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Uncontrolled Keywords: diabetes ketoacidosis; type 1 diabetes; type 2 diabetes; emergency department; point of care testing; ketones
Subjects: Medicine and health > Clinical medicine
Medicine and health
Depositing User: Dominic Walker
Date Deposited: 14 Dec 2016 09:48
Last Modified: 15 Dec 2016 09:50
URI: http://repository.uwl.ac.uk/id/eprint/2996

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